Normal 15 Chromosome
We each have two number 15 chromosomes, one inherited from our mother (M.) and one inherited from our father (P, paternal). The Angelman syndrome gene (UBE3A) is located at chromosome 15, band q12, as depicted. In the brain, the Angelman gene is primarily expressed from the maternally inherited chromosome 15. The diagrams below illustrate the four known genetic mechanisms that cause Angelman syndrome. Continue Reading →
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The Angelman Syndrome Foundation is dedicated to funding the highest caliber of research on Angelman syndrome. It is our hope that these funded researchers, and their collaborators and peers, will bring forth new discoveries that ultimately lead to safe and effective therapies that improve the quality of life for all with Angelman syndrome. Continue Reading →
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