KIK-AS

Participant Requirements

Below is a preliminary list of inclusion and exclusion criteria. See the full list of Eligibility Criteria on the clinical trials website.

Inclusion Criteria

• Diagnosis of Angelman syndrome
• Between 4 and 17 years old
• Stable seizure control (defined as clinically stable with no changes in antiepileptic medications over the prior 1 month before screening visit, other than weight associated dose adjustments)
• Ability to attend scheduled visits at the site location
• Ability to tolerate anesthesia 

Exclusion Criteria

• Any change in medications (excluding antiepileptic drugs) or diet intended to treat symptoms of AS (e.g. sleeping aids, supplements, ketogenic or low-glycemic index diet, other) over the prior 3 months before screening.
• Inability to walk/move independently or with an assistive device or caregiver hand-hold
• Any bleeding or platelet disorder
• Any clinically significant health conditions that could pose a safety risk
• Any active infection
• Use of any investigational drugs in the past 6 months