A combined molecular and electrophysiological approach to understanding cerebellar defects in Angelman syndrome
Individuals with AS have movement problems and are unstable walking. These findings have suggested that the cerebellum plays an important role in AS in causing these problems. In the Angelman mouse model, cerebellar function can be studied through the use of certain coordinated repetitive behaviors such as feeding and licking behaviors and that has been the basis for these studies. The purpose of this grant is to study these behaviors in the Angelman mouse model combined with detailed histological and protein chemistry studies of cerebellar neurons, and other neurons and cells in other brain regions.