Funding Research for Treatments and a Cure

Developmental Ube3a effects on language-related assessments in a mouse AS model
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R. Holly Fitch headshot R. Holly Fitch, Ph.D. University of Connecticut
2020

Developmental Ube3a effects on language-related assessments in a mouse AS model

Dr. Fitch’s lab has found that the Angelman syndrome mouse model has fewer vocalizations (communication) than typically developing mice.  This project proposes to find the brain circuitry responsible for the reduced communication in mice.  Preliminary studies suggest it is probably motor circuitry that is most important for vocalizations in the AS mouse model.  

This work will help us better understand the brain regions involved in speech and language disorders for AS, which will provide insight as to the therapeutic window for treating communication difficulties in AS.  

Slide explaining research study
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