Dr. Michael Greenberg Children’s Hospital Boston , Boston, MA
Investigation Of The Role Of UBE3A In Synapse Development
We know that UBE3A action inside brain cells is extremely complicated but the research of Dr. Greenberg and his lab has greatly helped to dissect and better understand this complexity. Using mouse models and using powerful genetic technologies to study individual neuron cells, their lab identified new protein targets that regulate synaptic development and activity. Importantly, these new proteins are related to other proteins for which druggable targets have been established and this area of research is creating new ideas about possible new pharmaceutical or other novel types of treatment approaches.