John Marshall, PhD Brown University, Providence, RI
Rescue of Angelman Syndrome Learning Deficits by an Investigational New Drug
$198,899 (2-year award)
As research improves our understanding of synapse function in normal individuals and how it is abnormal in those with AS, we are approaching an exciting time when therapeutic drug agents or chemicals can be tested in the AS mouse model. Accordingly, this grant funds an investigator who has experience in developing synaptic-related compounds that are active in improving synaptic function with the aim of improving cognitive function. Funding for this project is consistent with other efforts by ASF to explore novel avenues of drug treatment that may ameliorate or potentially cure the symptoms of AS.