CaMKII – Angelman Syndrome Foundation

December 22, 2019

Dissecting the roles of Ube3a in synaptic plasticity by analyzing synaptic function at the single cell level and utilizing ‘Network Analysis Proteomics’ strategy

$56,000 This grant-funded research was to a premier AS researcher who was instrumental in developing a mouse model for AS and who demonstrated that an important enzyme associated with the synapse, CAMKII, was inhibited or partially inactivated in Angelman mice. […]

December 22, 2019

Are the neurological symptoms of Angelman Syndrome reversible? An inducible mouse model for Angelman Syndrome

$76,600 This grant to Dr. Elgersma and his colleagues, built further upon his earlier significant work demonstrating that many of the neurological and behavioral features of the Angelman mouse model could be reversed by changing the phosphorylation status of an […]

December 21, 2019

Identification and Manipulation of the Phosphatases that Produce Aberrant Phosphorylation of CaMKII in Angelman Syndrome

$200,000 (2 years) Previous work on a major synaptic protein, Calcium/calmodulin-dependent protein Kinase II (CaMKII), suggests that it has a central role in producing the developmental deficits in Angelman syndrome (AS). This research seeks to better understand how CaMKII activity […]

articles and announcements

Categories: CaMKII

Dissecting the roles of Ube3a in synaptic plasticity by analyzing synaptic function at the single cell level and utilizing ‘Network Analysis Proteomics’ strategy

Are the neurological symptoms of Angelman Syndrome reversible? An inducible mouse model for Angelman Syndrome

Identification and Manipulation of the Phosphatases that Produce Aberrant Phosphorylation of CaMKII in Angelman Syndrome