$200,000 Motor deficits are common and debilitating, but not well-understood, symptoms of Angelman syndrome. AS results from the loss of the UBE3A gene. The development and study of animal models of AS that lack the same gene has advanced our […]
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$200,000 The goal of this study is to establish biomarkers of language function in Angelman syndrome. Language is a likely target for both behavioral and pharmaceutical treatment, as it represents a core deficit in Angelman syndrome and is a major […]
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Dr. Fitch’s lab has found that the Angelman syndrome mouse model has fewer vocalizations (communication) than typically developing mice. This project proposes to find the brain circuitry responsible for the reduced communication in mice. Preliminary studies suggest it is probably […]
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The aim of this study is to quantify the effect on communicative abilities of participants* with Angelman syndrome (AS) of high intensity and low intensity training of parents and caretakers in Augmentative and Alternative Communication (AAC). Parents will be taught […]
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$10,581 Individuals with AS are quite animated in their attempts at communication and can be pro-social even though they have severe speech impairment. Although fluent sign language is beyond the motor and cognitive abilities of those with AS, there is […]
Read more $11,541 Funds for this project built on earlier work by Dr. Calculator (above) and provided additional behavioral treatment strategies to improve communication through nonverbal methodologies.
Read more $31,087 One of the problems in obtaining optimal educational services for children with AS is that there is not much information regarding placement in inclusive classrooms and in other settings. What can we learn from parents and teachers about their […]
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Summary of Dr. Sennott study. Language allows us to share what matters to us with the people we care most about. Individuals with AS face major barriers to access language. Typically developing children learn to use speech to communicate only […]
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