The aim of this study is to quantify the effect on communicative abilities of participants* with Angelman syndrome (AS) of high intensity and low intensity training of parents and caretakers in Augmentative and Alternative Communication (AAC). Parents will be taught […]
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$35,000 We know that individuals with AS have a propensity for a happy demeanor and often have excessive laughter. We also know that they have pro-social behaviors that are distinctive from other types of genetic conditions. This study evaluated older […]
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$10,581 Individuals with AS are quite animated in their attempts at communication and can be pro-social even though they have severe speech impairment. Although fluent sign language is beyond the motor and cognitive abilities of those with AS, there is […]
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$25,000 UBE3A, the gene when disrupted causes AS, is present in all animal and insect species, thus indicating how important it is for normal neuronal function. These investigators were able to identify the equivalent of the UBE3A gene in Drosophila, […]
Read more$29,700 Visual media plays a powerful role in helping families and others understand the natural history and many of the day-to-day concerns that parents have for their children and adults with AS. This work combines the skills of individuals experienced […]
Read more $11,541 Funds for this project built on earlier work by Dr. Calculator (above) and provided additional behavioral treatment strategies to improve communication through nonverbal methodologies.
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$25,000 About 90% of individuals believed to have AS will have abnormal genetic tests that identify one of four mechanisms that can disrupt UBE3A function. There are however about 10% of individuals with apparent AS who have negative genetic testing […]
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$26,000 Funds for this project represent continued funding for this investigator to conduct expanded clinical trials to attempt to demonstrate the effect of providing methylation-rich dietary supplements to those with AS.
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