$30,000 The work related to this grant extended the long term interest of Dr. Summers in studying how individuals with AS learn and how their behaviors change based on carefully designed behavioral analysis methods in a structured environment. Most importantly, […]
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$170,202 (2 years) Previous research discoveries have indicated that one of the UBE3A target proteins, Arc (activity-regulated cytoskeleton-associated protein) plays a critical role in regulating synaptic plasticity and long-term information storage in the brain. By understanding how Arc is involved […]
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$200,000 (2 years) At approximately two weeks of age in a proven AS mouse model, there is an increase in the expression and subsequent activity of a specific molecule prior to other molecules in the AS brain, which results in […]
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Dr. Geeske Van Woerden and her lab will research the best time to correct certain symptoms of AS when Ube3a is restored in a mouse model. Overall, the research team attempts to answer the question: can certain behaviors or symptoms […]
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