$62,200 Dr. Weeber has performed crucial genetic and therapeutic studies on the AS mouse model and was instrumental in conducting one of the first experiments that rescued many of the neurophysiological and behavioral problems of the Angelman mouse. To help […]
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$80,000 The work in this grant extended our knowledge of brain regions that are affected when UBE3A is disrupted. Using the mouse model and studying the visual and brain cortex responses of each eye, this investigator and his laboratory were […]
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$70,000 One way to understand brain abnormalities in those with AS is to actually study individual neurons using state-of-the-art micro-testing methods, for example, measure directly the electrical activities associated with function of the synapse in a single neuron. This technique […]
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$75,000 It is known that UBE3A is important inside brain neurons especially at their membrane surfaces where the synapse facilitates communication between neurons. It has also been recognized that other cellular problems develop when UBE3A is defective and this laboratory […]
Read more $50,000 This grant supported a trial of levodopa-carbidopa treatment on AS mice. Levodopa is a dopamine precursor that is converted to dopamine in the brain and is commonly used as a treatment for Parkinson disease. AS mice and normal controls […]
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$77,866 Individuals with AS have movement problems and are unstable walking. These findings have suggested that the cerebellum plays an important role in AS in causing these problems. In the Angelman mouse model, cerebellar function can be studied through the […]
Read more $95,000 An important question about the developmental problems in AS is to what extent neurons change based on experience and how this is impaired in AS. One way to understand this is to use the Angelman mouse model to study […]
Read more $95,000 In this research project, AS mice were studied at the time of birth and throughout the early days of life under controlled conditions that create different degrees of visual experience. This project was funded in collaboration with Dr. Philpot (see […]
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