$76,600 This grant to Dr. Elgersma and his colleagues, built further upon his earlier significant work demonstrating that many of the neurological and behavioral features of the Angelman mouse model could be reversed by changing the phosphorylation status of an […]
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This project funds work on a special type of mouse model in which production of the UBE3A protein can be identified by use of a yellow fluorescent tag. This then enables the tracking and localizing of certain UBE3A proteins within […]
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$99,425 At the DNA level, UBE3A represents a single region of DNA molecules but when UBE3A makes its proteins multiple different proteins appear and these are termed isoforms. In this project, Dr. Jiang is evaluating some of the shorter protein […]
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$200,000 (2-year award) Dr. Peter Howley, a long-time investigator into the role of UBE3A, has been funded by ASF to conduct state-of-the-art studies that have promise for identifying new protein targets and interacting proteins for UBE3A. This work involves using […]
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$197,580 (2-year award) This project enabled Dr. Klann to continue his studies on the synapse and on the action of an important group of proteins, the neuregulins. At the neuronal cell membrane, these proteins are known to interact with an […]
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$198,899 (2-year award) As research improves our understanding of synapse function in normal individuals and how it is abnormal in those with AS, we are approaching an exciting time when therapeutic drug agents or chemicals can be tested in the […]
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$199,972 (2-year award) Funding for this grant is an attempt to promote research targeted to identifying agents or druggable compounds that may increase expression of UBE3A in brain neurons. Using multidisciplinary facilities, advanced genetic engineering and robotic drug analysis, this grant […]
Read more$25,000 – RDCRN Training Grant This proposal seeks to compare the yield of routine EEGs obtained as a standard in the Angelman Natural History protocol with two other types of EEG recordings to identify common EEG patterns. These patterns include […]
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