December 22, 2019
$95,000 An important question about the developmental problems in AS is to what extent neurons change based on experience and how this is impaired in AS. One way to understand this is to use the Angelman mouse model to study […]
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December 22, 2019
$95,000 In this research project, AS mice were studied at the time of birth and throughout the early days of life under controlled conditions that create different degrees of visual experience. In this situation, AS mice were housed in light […]
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December 22, 2019
$78,788 How can we better understand the problems of intellectual deficiency in AS? Recently it has been clear that one key to answering this question resides in better understanding of how neuronal synapses function. Neuregulins are important proteins involved in […]
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December 22, 2019
$76,055 Dr. Segal has significant experience in synthesizing molecules that bind to DNA and are able to regulate gene activity. ASF has provided funds to this investigator to pursue the possibilities that such agents, called artificial transcription factors, could have […]
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December 22, 2019
$98,450 ASF has supported on many fronts research strategies in an attempt to increase the expression of UBE3A in the AS brain. As discussed for previous grants, it is known that in each nerve cell a UBE3A gene is repressed […]
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December 22, 2019
$76,600 This grant to Dr. Elgersma and his colleagues, built further upon his earlier significant work demonstrating that many of the neurological and behavioral features of the Angelman mouse model could be reversed by changing the phosphorylation status of an […]
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December 22, 2019
This project funds work on a special type of mouse model in which production of the UBE3A protein can be identified by use of a yellow fluorescent tag. This then enables the tracking and localizing of certain UBE3A proteins within […]
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December 22, 2019
$99,425 At the DNA level, UBE3A represents a single region of DNA molecules but when UBE3A makes its proteins multiple different proteins appear and these are termed isoforms. In this project, Dr. Jiang is evaluating some of the shorter protein […]
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