December 22, 2019

The ubiquitin ligase E6-AP/UBE3A targets the polycomb repressive complex proteins Ring 1B and Bmi1 to ubiquitination and subsequent degradation: Structural and functional implications, and possible relationship to the pathogenesis of Angelman syndrome

$95,000 ASF foundation was proud to sponsor this research by Nobel Laureate Aaron Ciechanover who has been instrumental in characterizing the ubiquitin protein degradation system, a fundamental component of how neurons degrade or adjust proteins in order to function normally. […]

Read more