$150,000 UBE3A is a protein that labels other proteins for disposal. It is thought that accumulation of proteins that would normally be “trashed” causes the deficits in AS. Using stem cells generated from Angelman syndrome patients or stem cells genetically […]
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$50,000 Work from this grant was part of several projects funded by ASF in order to learn more about UBE3A and its relationship to the larger, complex system of protein degradation (called the ubiquitin-proteasome pathway) that is important to all […]
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$80,000 UBE3A function in the cell has remained elusive especially in terms of how UBE3A protein action relates to other proteins. Thus, researchers have been trying to identify “targets” (meaning proteins) that UBE3A is acting upon in order to either […]
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$95,000 ASF foundation was proud to sponsor this research by Nobel Laureate Aaron Ciechanover who has been instrumental in characterizing the ubiquitin protein degradation system, a fundamental component of how neurons degrade or adjust proteins in order to function normally. […]
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$199,705 (2 years) This research project aims to identify and characterize proteins in the brain that are affected by the absence of UBE3A. These proteins serve an unknown purpose in brain development. This research will help provide insight into how […]
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This research project is jointly funded by the ASF and Dup15q Alliance. UBE3A is a protein that tags other proteins to be disposed of in the cell. It interacts with another protein, HERC2, which also has a similar function. Individuals […]
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