Neuregulin-dependent alterations in glutamate receptor function and LTP in Angelman Syndrome model mice
How can we better understand the problems of intellectual deficiency in AS? Recently it has been clear that one key to answering this question resides in better understanding of how neuronal synapses function. Neuregulins are important proteins involved in synapse function as they help reorganize and fully develop the synapse so that it is better able to respond to the types of stimulations and experiences that result in learning and memory. Dr. Klann’s studies have delineated how neuregulins relate to synaptic development and how neuregulins are affected in the Angelman mouse model, and they provide one more important link to our better understanding of the synapse problems in AS.