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Natural History Study | Nausea


Natural History Study

The Natural History study is a research project designed to improve our knowledge of Angelman syndrome (AS) by collecting information on individuals with AS once a year for 5-10 years (or more) at one of our six study sites (San Diego, Houston, Nashville, Greenwood, Boston or the newly added Cincinnati).  All of the same evaluations are done at each site, and all of the data are entered into a single database so that the researchers can learn more about AS.

Boston Site
Dr. Wen Hann Tan
Children’s Hospital Boston Division of Genetics
300 Longwood Ave
Boston, MA 02115
Telephone: 617-355-4697 Contact Person: Jennifer Willen, MS

Cincinnati Site
Logan Wink M.D.
Cincinnati Children’s Hospital Medical Center
3333 Burnet Ave MC 3014
Cincinnati, Ohio 45229
Contact Person: Tori Schaefer
Telephone: 513-803-3740

Greenwood Site
Steve Skinner, MD
Director of Clinical Services
Greenwood Genetic Center 1 Gregor Mendel Cr
Greenwood, SC 29646
Contact Person: Fran Annese, LMSW
Telephone: 864-941-8100

Houston Site
Carlos Bacino, MD, FACMG
Director, Kleberg Genetics Clinic Medical
Director, Kleberg Cytogenetics Laboratory Associate
Professor Department of Molecular and Human Genetics
Baylor College of Medicine
Texas Children’s Hospital
Clinical Care Center
6701 Fannin, Suite 1560 Houston, TX 77030
Contact Person: Beverly Feldman, RN, MSN
Telephone: 832-822-4301 Fax: 832-825-1515

Nashville Site
Principal Investigator: Marshall Summar, MD
Vanderbilt University Medical Center
Nashville, Tennessee
Contact Person: Amy K. Wilson, MA
Telephone: 615-322-8093

San Diego Site
Lynne M. Bird, MD
Dysmorphology/Genetics, Children’s Hospital, San Diego
3020 Children’s Way #5031
San Diego, CA 92123
Telephone: 858-966-5840
Contact Person: Rachel Winograd, RN

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To prevent the nausea sometimes caused by general anesthesia medication, some parents request that an anti-nausea drug be administered in the IV during surgery.

Brat Diet

The BRAT diet is a diet for patients with gastrointestinal distress such as diarrheadyspepsia, and/or gastroenteritis. The BRAT diet is a bland diet that consists of foods that are low in fiber. Low-fiber foods were recommended as it was thought that foods high in fiber cause gas and possibly worsen gastrointestinal upset.

BRAT is an acronym for bananasriceapplesauce, and toast, the staples of the diet. Extensions to the BRAT diet include BRATT (with tea), BRATTY (with tea and yogurt), and BRATCH (with chicken, often boiled). Sometimes, the “T” represents tapioca. In addition to dietary restrictions, medical professionals recommended that all patients, regardless of age, drink plenty of fluids to prevent dehydration, along with oral rehydration solutions to replace the depleted electrolytes to avoid salt imbalance. Severe, untreated salt imbalance can result in “extreme weakness, confusion, coma, or death.

Foods to avoid if you suffer from nausea include:

  • Greasy, oily, and spicy foods
  • Milk and dairy products
  • Alcohol
  • Caffeine
  • Raw vegetables like corn, cabbage, onions and beets
  • Salmon and sardines
  • Pork and veal
  • Fruits such as oranges, grapefruits, cherries, berries, and figs

If you or anyone you know is suffering from any of the following symptoms along with nausea, contact your doctor or emergency room immediately:

  • If you have been vomiting for more than a day with no respite
  • If there is no retention of fluids for 8 hours if you are a child or 12 hours in the case of adults
  • If there is blood or a coffee-ground like substance in your vomit
  • If you have a headache, stomachache or stiff neck
  • If you are exhibiting signs of dehydration such as dry mouth, sunken eyes, increase in thirst, and infrequent urination
  • If your child has taken aspirin
  • If your child is lethargic or unusually irritable
  • If the nausea is prolonged
  • If home remedies are not working
  • If there was an head injury
  • If there is a fever (especially in the case of children)
  • If there is a feeling of confusion and lack of alertness
  • If there is a rapid pulse or irregular heartbeat
  • If there is difficulty in breathing

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