December 22, 2019
$200,000 (2-year award) Dr. Peter Howley, a long-time investigator into the role of UBE3A, has been funded by ASF to conduct state-of-the-art studies that have promise for identifying new protein targets and interacting proteins for UBE3A. This work involves using […]
Read more
December 22, 2019
$197,580 (2-year award) This project enabled Dr. Klann to continue his studies on the synapse and on the action of an important group of proteins, the neuregulins. At the neuronal cell membrane, these proteins are known to interact with an […]
Read more
December 22, 2019
$198,899 (2-year award) As research improves our understanding of synapse function in normal individuals and how it is abnormal in those with AS, we are approaching an exciting time when therapeutic drug agents or chemicals can be tested in the […]
Read more
December 22, 2019
$199,972 (2-year award) Funding for this grant is an attempt to promote research targeted to identifying agents or druggable compounds that may increase expression of UBE3A in brain neurons. Using multidisciplinary facilities, advanced genetic engineering and robotic drug analysis, this grant […]
Read more
December 22, 2019
$25,000 – RDCRN Training Grant This proposal seeks to compare the yield of routine EEGs obtained as a standard in the Angelman Natural History protocol with two other types of EEG recordings to identify common EEG patterns. These patterns include […]
Read more
December 22, 2019
$92,144 – 1-year With previous support from the ASF, Dr. Elgersma engineered a UBE3A- inducible mouse in which the UBE3A gene (responsible for causing AS) is non-functional when the mouse is born. However, by a medication injection at any desired […]
Read more
December 21, 2019
$170,202 (2 years) Previous research discoveries have indicated that one of the UBE3A target proteins, Arc (activity-regulated cytoskeleton-associated protein) plays a critical role in regulating synaptic plasticity and long-term information storage in the brain. By understanding how Arc is involved […]
Read more
December 21, 2019
$200,000 (2 years) Previous work on a major synaptic protein, Calcium/calmodulin-dependent protein Kinase II (CaMKII), suggests that it has a central role in producing the developmental deficits in Angelman syndrome (AS). This research seeks to better understand how CaMKII activity […]
Read more