Angelman Syndrome Foundation opener
  • Walk
  • Contact Registry
  • News
  • Blog
DOnate
  • What is Angelman Syndrome
    • Symptoms and Causes
    • Testing and Diagnosis
    • Genetics of AS
    • Photo Gallery
  • For Parents
    • Newly Diagnosed
    • Accomplishments of Individuals
    • Participate in Research Studies
    • Angelman Therapeutics
  • Research
    • ASF Funded Research
    • Call for Proposals
    • Current Research Studies
    • LADDER
    • Research Funding Philosophy
  • Make an Impact
    • ASF Cure Club
    • Ways To Donate
    • Fundraise
    • Committees & Groups
    • Send Encouragement
    • Shop & Support ASF
    • Volunteer Opportunities
  • Clinics
    • Find a Clinic
    • Clinic Patient Survey
    • For Clinicians
    • Jacob Pritzker Fellowship Program
    • FAQs
  • Resources
    • Search by Topic
    • Adult Resources
    • ASF Family Resource Team
    • ASF Family Fund
    • ASF Family Champions
    • Angelman Syndrome A to Z
    • ASF Podcast
    • Behavior Resources
    • Communication Resources
    • Counseling Services
    • Educational Webinars
    • Federal Resources
    • IEP Resources
    • International AS Resources
    • Medical Resources
    • Seizures
    • Sibling Programs
    • State Resources
  • Events
    • ASF Walk
    • Conferences and Symposia
    • Bank of America Chicago Marathon
  • About
    • Contact ASF
    • Contact Registry
    • Our Partners
    • Board of Directors
    • Communication Advisory Committee
    • Financial Transparency
    • History of ASF and Angelman Syndrome
    • Parent Advisory Committee
    • Scientific Advisory Committee
    • Receive Texts & Emails
    • Privacy

articles and announcements

Categories: Mouse Model

December 22, 2019

Rescue of Angelman Syndrome Learning Deficits by an Investigational New Drug

$198,899 (2-year award) As research improves our understanding of synapse function in normal individuals and how it is abnormal in those with AS, we are approaching an exciting time when therapeutic drug agents or chemicals can be tested in the […]

Read more
Ben Philpot, PhD
December 22, 2019

Novel therapeutics for Angelman syndrome by manipulating Ube3a expression

$199,972 (2-year award) Funding for this grant is an attempt to promote research targeted to identifying agents or druggable compounds that may increase expression of UBE3A in brain neurons. Using multidisciplinary facilities, advanced genetic engineering and robotic drug analysis, this grant […]

Read more
December 22, 2019

Association of Sleep and Behavior in Children with Angelman Syndrome

$25,000 – RDCRN Training Grant This proposal seeks to compare the yield of routine EEGs obtained as a standard in the Angelman Natural History protocol with two other types of EEG recordings to identify common EEG patterns. These patterns include […]

Read more
Dr. Ype Elgersma
December 22, 2019

An inducible mouse model for Angelman Syndrome: Follow up

$92,144 – 1-year With previous support from the ASF, Dr. Elgersma engineered a UBE3A- inducible mouse in which the UBE3A gene (responsible for causing AS) is non-functional when the mouse is born.  However, by a medication injection at any desired […]

Read more
December 21, 2019

Investigating the Causal Role of Arc in Angelman Syndrome Pathogenesis

$170,202 (2 years) Previous research discoveries have indicated that one of the UBE3A target proteins, Arc (activity-regulated cytoskeleton-associated protein) plays a critical role in regulating synaptic plasticity and long-term information storage in the brain.  By understanding how Arc is involved […]

Read more
December 21, 2019

Identification and Manipulation of the Phosphatases that Produce Aberrant Phosphorylation of CaMKII in Angelman Syndrome

$200,000 (2 years) Previous work on a major synaptic protein, Calcium/calmodulin-dependent protein Kinase II (CaMKII), suggests that it has a central role in producing the developmental deficits in Angelman syndrome (AS).  This research seeks to better understand how CaMKII activity […]

Read more
December 21, 2019

Examining rescue of neurological deficits in Angelman syndrome mice by expression of the E6-AP isoforms

$84,011 In this study, Dr. Dindot plans to investigate whether gene therapy in the AS mouse (using lentiviruses as the vector) is a viable therapeutic option, and thus a future possibility for individuals with AS. He will also examine the […]

Read more
Dr. Mark Zylka
December 21, 2019

Molecular mechanisms and biomarkers of a candidate Angelman syndrome therapeutic

$200,000 – 2-years Dr. Zylka’s lab will expand on the work previously funded by ASF that led to the identification of a family of topoisomerase inhibitors that can unsilence the paternal UBE3A gene.  In order to learn more about this […]

Read more
Page 5 of 8« First«...34567...»Last »

Recent Posts

  • GFAS Ukraine and ASF partner to Launch Clinic in Ukraine
  • AngelmanUK and ASF partner to launch clinics in the UK
  • LADDER Database Receives Transformational Dataset from Ovid Therapeutics
  • ASF Partners with Families in UAE to Expand Clinical Network
  • ASF to Host Screening of Caregiver Documentary, Unseen

Browse

  • What is Angelman Syndrome
  • For Parents
  • ASF Funded Research
  • Make an Impact
  • Events
  • About
  • Angelman Resources & Education
  • Contact Registry
  • News
Address Angelman Syndrome Foundation
3015 E. New York Street
Suite A2 #285
Aurora, IL 60504
Phone800.432.6435 Emailinfo@angelman.org

Connect

  • facebook
  • twitter
  • linkedin
  • instagram
  • pinterest
  • rss
  • youtube

The Mission

The mission of the Angelman Syndrome Foundation is to advance the awareness and treatment of Angelman syndrome through education and information, research, and support for individuals with Angelman syndrome, their families and other concerned parties. We exist to give all of them a reason to smile, with the ultimate goal of finding a cure.

  • 4-star charity navigator logo
  • Combined Federal Campaign logo
  • Community Congress logo
Copyright © 2023 Angelman Syndrome Foundation. ALL Rights Reserved. | Site design: BRAND INSPIRATION, LLC